Lanli Bio Granted Invention Patent: Breakthrough Solves Fish Collagen Peptide's "Odor & Absorption" Industry Challenges

Dezhou Lanli Biotechnology Co., Ltd. has officially been granted a national invention patent for its independently developed "Preparation Method of a Beauty-Enhancing Fish Collagen Peptide" (Patent No.: ZL 2024*****52.2, Authorization No.: CN117534748B). This marks another major technological breakthrough for Lanli Bio in the bioactive peptide sector, establishing the company as an industry leader in small-molecule fish collagen peptide production and deodorization technology.

Industry Pain Points: Two Ceilings for Fish Collagen Peptides

Fish collagen peptides have become a highly sought-after ingredient in the beauty and wellness industries due to their structural affinity with human skin and sustainable sourcing. However, the industry has long grappled with two pain points that are difficult to address simultaneously:

First, the trade-off between molecular weight and efficacy. Shorter peptide chains are more readily absorbed through the skin, but conventional enzymatic hydrolysis processes generally produce peptides with higher molecular weights, limiting penetration efficiency. Conversely, aggressively pursuing smaller molecules often results in reduced peptide efficacy.

Second, the persistent fishy odor. Peptides derived from fish sources commonly carry a fishy smell, which directly restricts their dosage levels and application scope in high-end cosmetics and oral beauty products.

The invention patent granted to Lanli Bio provides a systematic solution to both challenges.

Technological Breakthrough: Three-Stage Enzymolysis + Triple Deodorization

The patented process uses cod bone and cod skin as raw materials and establishes a full-chain workflow from pretreatment to finished product. Its core innovations lie in two dimensions:

I. Three-Stage Targeted Enzymolysis — Precision Lock on Sub-1 kDa Molecules

The process employs a sequential three-stage enzymolysis route using bromelain → pepsin → acyltransferase I, with precisely controlled reaction environments, pH levels, and temperatures at each stage:

• Stage 1: Initial cleavage with bromelain under an MRM molecular resonance environment;

• Stage 2: Further degradation with pepsin under acidic conditions;

• Stage 3: Deep enzymolysis with acyltransferase I combined with 25 kHz ultrasonic assistance, followed by separation through a 1 kDa ultrafiltration membrane to yield small-molecule peptides with molecular weights entirely below 1 kDa.

Experimental data demonstrates that peptides produced by this process achieve 100% of molecular weight below 1 kDa, with total nitrogen content stable at 15.86%–15.88% and ash content below 0.32%, reflecting excellent product purity and consistency.

II. Triple Deodorization — Eliminating Fishy Odor at the Source

Unlike the industry's common "end-stage masking" approach, this patent incorporates targeted deodorization at three stages — pre-treatment, mid-treatment, and post-treatment:

• Pre-treatment: Combined soaking in NaOH solution and ginger juice to remove odor-causing substances directly from the raw material;

• Mid-treatment: Further purification using a mixed solution of sodium polyglutamate, allantoin, and 2-hydroxypropionic acid;

• Post-treatment: Final treatment with a compound solution of sodium guaiazulene sulfonate, coco-glucoside, and hexahydrothymol.

The synergistic effect of triple deodorization ensures the final product is completely free of fishy odor, allowing it to be directly incorporated into cosmetic formulations without additional fragrance masking.

Efficacy Validation: Whitening, Anti-Wrinkle, and Antibacterial Benefits Confirmed

The patent specification documents a comprehensive suite of efficacy verification tests:

• Safety: Skin irritation, skin sensitization, and in vitro cytotoxicity tests conducted in accordance with the Safety and Technical Standards for Cosmetics all confirmed the product as safe and non-toxic;

• Antibacterial activity: Inhibition zone diameters reached 15.3–15.5 mm against Staphylococcus aureus, 14.2–14.3 mm against Propionibacterium acnes, and 12.3–12.5 mm against Malassezia, demonstrating strong antibacterial performance;

• In-use results: After approximately 28 days of continuous use, subjects showed visibly reduced fine lines and diminished dullness, with no unpleasant product odor.

Lanli Bio: Building Core Competitiveness in Bioactive Peptides Through Patented Technology

Founded in 2017 and headquartered in Linyi Economic Development Zone, Dezhou, Shandong Province, Dezhou Lanli Biotechnology Co., Ltd. is a high-tech enterprise specializing in the R&D, production, and sales of bioactive peptides. The company's main product lines include fish collagen peptide, bovine collagen peptide, soybean peptide, and other animal-, plant-, and marine-derived active peptide products. With a facility covering approximately 200 mu (≈133,000 m²), 126 sets of professional large-scale production equipment, and an annual production capacity of 19,000 tons, Lanli Bio is one of China's leading peptide ingredient manufacturers.

To date, the company holds 82 independently developed patents, including 58 invention patents and 24 utility model patents. It has obtained ISO9001 Quality Management System certification, HACCP certification, and HALAL certification, with products exported to Southeast Asia, North America, Australia, and other regions.

The granting of this invention patent for the "Preparation Method of a Beauty-Enhancing Fish Collagen Peptide" further strengthens Lanli Bio's technological moat in the beauty peptide segment. The company will continue to drive independent R&D, delivering higher-quality, higher-activity peptide ingredient solutions to beauty and wellness brands worldwide.

About Dezhou Lanli Biotechnology Co., Ltd.

Dezhou Lanli Biotechnology Co., Ltd. is a leading supplier of bioactive peptide ingredients in China. Committed to cutting-edge enzymolysis technology and strict quality control, the company provides one-stop supply of full-category peptide ingredients for the food, cosmetics, and health supplement industries. For more information on our products and technologies, please contact us.